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The film opens with adventurous and creative third grader Ramona Quimby (Joey King) playing on the monkey bars during recess with her best friend, Howie Kemp (Jason Spevack). Although Ramona has fun with Howie, her mood changes when she goes home and finds out disturbing news.Mr. Quimby loses his job and the family is in severe debt. Ramona overhears her parents' conversation and decides that she is going to sell "delishus lemonade" in order to make money. Beatrice (Selena Gomez), Ramona's sister, sees Henry Huggins (Hutch Dano), the paper boy. She accidentally spits lemonade in his face because a fly lands in her glass. She then becomes angry at Ramona, saying that Ramona embarrassed her sister in front of Henry by spitting lemonade in his face and nicknaming her "Beezus," instead of Beatrice (because Ramona couldn't say Beatrice when she was a baby). After that mistake, she decides to have a $20 car wash but that backfires also.After accidentally painting Hobart's car multiple colors, she retires. The next day, Mr. Quimby accidentally gives her a raw egg in her lunch, and after cracking the egg on her head, gets it in her hair. Mrs. Meacham tries to take the raw egg out of her hair, but most of it remains stuck in her hair. Instead of the photographer saying "Cheese," he says "Peas," causing Ramona to interrupt with a great big "Eww!," ruining her portrait. The next day in music class, Ramona throws up on the drums, causing her to be picked up by Robert. She then stays at home with Beezus. After trying to make dinner for her parents, the pan catches fire. Ramona interrupts Beezus on the phone with Henry, so Beezus yells at Ramona for always being a little pest and ruining her love life.