In a wonderful life you play as a boy and marry a girl, another wonderful life has you playing a girl marrying a boy and I think there's slight differences in special items they might be given by different people but I'm not sure havnt played these in a long time. As far as I know that's it but there might be other differences I can't remember. Look it up on google or gamefaqs. I would but I'm using my iPhone right now till my laptops back up