FREE: Christine Baranski (Diane Lockhart on the Good Wife) Autograph 8x10

Baranski was featured as Cybill Shepherd's hard-drinking friend Maryanne Thorpe in the CBS sitcom Cybill, which ran from 1995 until 1998, during which time she hosted Saturday Night Live and won an Emmy Award as best supporting actress in a comedy series along with three other nominations.

In 1999 Baranski received an Emmy nomination for a guest starring role as an intimidating radio psychiatrist on an episode of the NBC series Frasier. She had an uncredited role in the series Now and Again as the voice of Roger's overbearing wife Ruth, who was never seen by viewers.

She later appeared in the 2000–2001 sitcom Welcome to New York and, with John Laroquette, in the 2003–2004 NBC sitcom Happy Family. She co-starred with Bernadette Peters in a pilot for an ABC sitcom, Adopted, in 2005, which was not picked up. She also played Faith Clancy, the mother of Jim Clancy in Ghost Whisperer.

She portrayed a librarian named Sonja Umdahl in the episode "Dick and the Single Girl" of the series 3rd Rock from the Sun.[11]

She guest starred in The Big Bang Theory as Dr. Beverly Hofstadter, a bespectacled and unemotional expert in psychiatry and neuroscience who is the mother of one of the protagonists, Leonard Hofstadter. She appeared in the second season episode entitled "The Maternal Capacitance", for which she received an Emmy nomination. Due to the popularity of her first appearance, Baranski returned in the third season for the Christmas episode, "The Maternal Congruence" receiving another Emmy nomination.

Since 2009, she has played the role of Diane Lockhart, a top litigator and senior partner of a Chicago law firm on The Good Wife. She was nominated for Outstanding Supporting Actress in a Drama Series for an Emmy in 2010.